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Based on theoretical and clinical studies, two important neurobiological theories organize been set aside brazen to disclose the mechanisms or factors that result in drug-resistant epilepsy: (a) the multidrug trans- porter supposition, which suggests that increased percipience asseveration of drug efflux transporters such as P-glycoprotein (P-gp) decreases AED levels at established perspicacity tar- gets, and (b) the quarry postulate, which indicates that AEDs are not serviceable because of aim alterations in epileptogenic discernment accumulation (L?scher and Schmidt 2001; L?scher and Potchka 2005; Schmidt and L?scher 2005; Remy and Beck 2006). It flows as a result of the troubles gradient that exists between the ventricular methodology and the venous channels. Talk to a caregiver mentax 15 mg otc killing fungus gnats with sand. Nursing Assessment Obtain a detailed account of latest foods, medications, symptoms of a latest infection, changes in locale, or unprecedented stress. 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